Sziasztok!

Elsosorban fiatal matematikusoknak, biologusoknak es orvosoknak szol a
kovetkezo nyari iskola bejelentes.

A szervezok szerint a 35 ev alatti jelentkezok jo esellyel palyaznak
penzugyi tamogatasra.

Kovacsvolgyi Istvan



MATHEMATICS IN CELL PHYSIOLOGY AND PROLIFERATION.

===================
Second Announcement
===================

In the same spirit and hopefully with the same success as the First
Summer School, which took place in St. Flour (France 1997), a Second
Summer School of Mathematical Biology will take place in Termoli (CB,
Italy) between June 6 and June 19, 1999.

The school is organized by the French Society for Theoretical Biology
(SFBT) and by the Centro Fisiopatologia dello Shock and Istituto
Analisi dei Sistemi ed Informatica of the Italian National Research
Council (CNR). The school is conducted in close collaboration with the
Mario Negri Pharmacological Research Institute.

The school is sponsored by:
- European Commission
- CNR Strategic Project "Metodi e Modelli Matematici nello
  Studio dei Fenomeni Biologici"
- Istituto di Analisi dei Sistemi ed Informatica del CNR
- Centro CNR di Studio per la Fisiopatologica dello Shock
- Universite' de Pau et des Pays de l'Adour
- Rice University, Houston
- Comune di Termoli


The subject of the school will be mathematical methods applied to the
study of cell and molecular biology. The goal of the school is to
offer participants a presentation of some mathematical techniques
widely used in modelling problems in cell physiology and
proliferation, together with a review of some such problems of                 
contemporary relevance. The target audience is mainly composed of
advanced graduate students and post-graduates in the life sciences and
in mathematical disciplines (math, applied math, physics,
engineering). Applications are also encouraged from senior researchers
who may wish to explore a different field or take part in
interdisciplinary studies.


An updated description of the school may be found at the web page
        http://space.tin.it/scienza/hjcas/biomasch.htm
The school can also be contacted at the email address
                     


The school will be held at the Hotel Meridiano in Termoli. Termoli is
a pleasant seaside town in southern Italy, on the Adriatic coast. The
town features a tiny medieval village perched on a rocky promontory
thrust out on the sea, as well as a modern part towards the interior
and along the beaches north and south of the rock. Weather is mild to
warm, sunny most of the time. Termoli can be reached by train from the
following italian cities: Rome (5 hours), Milan (6.5 hours), Bologna
(4.5 hours), Pescara (1 hour), Bari (2 hours), Naples (4.5 hours).

Classes: Duration of the school is two weeks, including 11 days of
classes, Monday through Friday and Saturday morning. Each day there
will be 8 or 9 lecture units of 40 min by the staff and by invited
speakers, practice sessions and lectures contributed by participants.

Two afternoon sessions each week will be carried out at the Mario
Negri Pharmacological Research Institute (Consorzio Mario Negri Sud,
Santa Maria Imbaro, Chieti), the purpose being to expose the
participants of the school to real-life biological problems. Mario
Negri researchers will illustrate their work and show laboratory
experimental tecniques and measurements.

The language of the school is English. Most school activities will
take place in the same hotel where rooms and meals are provided. Each
lecture sequence (detailed below) will be completed in a single week,
more biological subjects being treated in the first week and more
mathematical subjects being treated in the second week. Collected
notes will be provided to the school participants.

The number of participants is limited to 70. Given the funding
obtained from the European Commission and other sources, the standard
cost to participants is 750 euro covering all foreseen school
activities, including full accomodation (three-star hotel, double
room, from Sunday June 6th to Saturday June 19th, 1999), registration
fee and teaching material, social programme, transportation to and
from the Negri Institute.

Further substantial cost reduction (up to the entire cost) is possible
for participants qualifying for the following scholarships:

TMR (European Commission): scholarships reserved to participants 35
years ofage or younger, from the European Community and affiliated
countries (Austria, Belgium, Denmark, Finland, France, Germany,
Greece, Ireland, Italy, Luxembourg, the Netherlands, Portugal, Spain,
Sweden, United Kingdom, Iceland, Israel, Liechtestein and Norway).

INCO (European Commission): scholarships reserved to participants 35
years of age or younger, from Eastern European and assimilated
countries (Albania, Armenia, Azerbaidjan, Belarus, Bosnia-Herzegovina,
Bulgaria, Cyprus, Czech Republic, Estonia, FYROM, Georgia, Hungary,
Latvia, Lithuania, Malta, Moldova, Poland, Rumania, Russia, Slovakia,
Slovenia, Turkey, Ukraine).

World (School Organizing Committee): scholarships to be assigned by
the School independently of TMR or INCO criteria.

Prospective participants compiling the (webpage, email, fax or mail)
application will receive a Financial Support Form: all scholarships
will be assigned on the basis of the academic and financial
information submitted in the Financial Support Form.

By April 20th, each applicant will receive communication of admission
to the school, of proposed support (if appropriate), of the amount to
be paid for pre-registration, and of the modalities of payment. Pre-
registration is strongly advised to guarantee admission at the
conditions outlined above.


Calendar:

September  1998: First announcement, topics covered
February   1999: Second announcement, program and logistics
April 15   1999: Deadline for submission of financial support form
April 20   1999: Communication of admissions and financial support
                 to participants. Pre-registration opens.
May 1      1999: Deadline for submission of contributed presentations
May 20     1999: Pre-registration closes. Final announcement.


June 1999
Sunday     6  Welcome and registration.
Monday     7  School starts
Friday    18  School ends
Saturday  19  Farewell breakfast, instructors' meeting



Scientific Committee:
Z. Agur (Israel), O. Arino (France, President), A. De Gaetano(Italy),
M.B. Donati(Italy), A. Gandolfi(Italy), M.Kimmel(USA), M. Mackey
(Canada), E. Sanchez (Spain), A. Swierniak(Poland), P. Ubezio(Italy).

Organizing Committee: O. Arino, A. De Gaetano (Managing Director), A.
Gandolfi, M. Kimmel.


Instructors and invited lecturers:
Zvia Agur, Saverio Alberti, William Amos, Ovide Arino, Michael Beil,
Jacques Belair, Edoardo Beretta, Alessandro Bertuzzi, Vincenzo
Capasso, Ranajit Chakraborty, William Coleman, Carlo Croce, Andrea
DeGaetano, Luigi Del Vecchio, Alberto Gandolfi, Raffaella Giavazzi,
Albert Goldbeter, Kristian Helin, Thomas Hoefer, Mimmo Iannelli, Marek
Kimmel, Tanya Kostova, Sophie Lelievre, Michael Mackey, Joseph
Mahaffy, Luigi Preziosi, Eva Sanchez, Damien Schoevaert, Andrzej
Swierniak, Ziad Taib, Paolo Ubezio, Jany Vassy, Vladimir Vatutin,
Glenn Webb.




TOPICS COVERED IN THE LECTURE SEQUENCES AND INVITED TALKS

Note: last minute rearrangements are possible for some lectures.



FIRST WEEK
==========


TUMOR CELL BIOLOGY
(S. Alberti, R. Giavazzi and K. Helin)

- Introduction: cell structure and function.
- Molecular mechanisms of cell cycle progression.
- Deregulation of cell cycle control in cancer.
- Cell membrane molecules that regulate tumor growth rates and
  patterns of tumor growth.
- Trop-regulated cell-cell adhesion in normal and tumorigenic cells.
- Angiogenesis in tumors.

Two additional units are to be announced.


CONTROL OF HAEMOPOIESIS
(Michael Mackey, Joseph Mahaffy and Jacques Belair)

- Periodic Hematological Diseases: Pathology, Modeling, and Treatment
(two units).
- Peripheral Control of Red Blood Cell Production (two units).
- Peripheral Control of White Blood Cell Production (two units).
- Stem Cell Dynamics:  Understanding Cyclical Neutropenia and Periodic
Leukemia (two units).
- Regulation of Platelet Production by Thrombopoietin (two units).




CYTOMETRY AND PARAMETER ESTIMATION
(S. Alberti, A. Bertuzzi, A. De Gaetano and L. Del Vecchio)

- Basic flow cytometry.
- Characterization of asynchronous exponential growth.
- Models for the analysis of data from asynchronous growth.
- Evaluation of cell cycle effects of drugs.
- Proliferation markers and detection of cell death.
- Gene expression analysis by flow cytometry and confocal microscopy.
- CD45-driven identification of normal and leukemic cells in human
bone marrow.
- Basic geometry of parameter estimation for nonlinear models.
- Fundamental results for least-squares and maximum likelihood
estimators.
- Curvature, confidence intervals and model choice.
- Population parameter estimation for nonlinear models.




CYTOSKELETON AND REGULATION OF CELL FUNCTION
(Jany Vassy, Sophie Lelivre, Michael Beil, Damien Schoevaert and
Stphanie Portet)

- Tissue architecture and gene expression, study of tissue matrix in
three-dimensional models of cell culture.
- Cytoplasmic cytoskeleton as a link between cell environment and
nucleus.
- Non-chromatin structure of the nucleus or nuclear matrix, its
interaction with chromatin structure and its role in the regulation of
gene expression.
- Automated image analysis of the cytoskeleton architecture. Methods
and applications.
- Image analysis of the cytoskeleton in cell movement.
- Modelisation of the architecture of cytokeratin networks.


ROUND-TABLE: the role of biomathematics in large biological research
institutions and corresponding career openings for young
biomathematicians.





SECOND WEEK
===========


STRUCTURED CELL POPULATIONS
(Eva Sanchez, Ovide Arino, Tanya Kostova and Glenn Webb)

- Asynchronous exponential growth and semigroup theory. Existence of
steady-state distributions. Generalities on semigroup theory. Positive
semigroups.
- Size-density models.Syngle type models. Models with two
compartments. Size-age density models.
- Time continuous daughter cell models. Model with deterministic
lifelength. Model with stochastic lifelength.
- A short review of other linear structured cell population models.
Comparison of approaches to modeling of cell population dynamics.
- Introduction to nonlinear models. Unequal division. Selective
regulation of cell population growth.
- Structured population models of the blood cell production system.
Chaotic behavior in maturity structured models.
- Structured population models of limited proliferative capacity in
dividing cell lines. Telomere fragment shortening on the ends of
chromosomes.
- Structured population models of tumor cord cell migration. Cell
kinetics in the vascularized steady state.
- Examples  of Age- and Size- Structured Models in Cellular Biology.
What does Numerical Solving mean? The Grid and the Step.
- Interpolation, Quadratutures, Order of Approximation, the Error,
Runge-Kutta Methods. Outline of Several Numerical Methods to Solve
Age- and Size- Structured Models. First, second, high accuracy
methods.




MODELLING  CANCER CHEMOTHERAPY
(Zvia Agur and Andrzej Swierniak)

- The use of mathematical models for understanding the cell cycle
clock in mammalian cells and its crackdown in cancer.
- Optimizing cell-cycle specific chemotherapy: insights gained from
mathematics (two units).
- Introduction to optimal control, controllability, observability.
The Bellman principle of optimality.
- Dynamic programming, application of dynamic programming to discrete-
time systems, the discrete LQ problem.
- Pontryagin maximum principle, application of the maximum principle
to continuous LQ problems and bang-bang control.
- Introduction to stochastic optimization (dynamic programming
approach), LQG problem, problem with Markovian jumps JLQ.
- Examples of applications in optimization of cancer therapy.

Two additional units are to be announced.



POPULATION GENETICS OF ORGANISMS AND CELLS
(William Amos, Ranajit Chakraborty and Marek Kimmel)

- Basic principles of genetics of diploid organisms: chromosomes,
genes, alleles, DNA, segregation, and recombination.
- Genetics of populations: mutation, genetic drift, selection.
- Important loci systems: autosomal and sex-linked loci, mitochondrial
DNA, repeat-DNA.
- Genetics of unicellular organisms, somatic cells and organelles.
- Estimation of relatedness of individuals.
- Models of mutational processes: Markov Chain models, Infinite Allele
and Infinite Site Model and Stepwise Mutation Model.
- Wright-Fisher-Moran model of genetic drift.
- Coalescence: the backward look at population genetics processes.
Ancestral stochastic processes. Connection with branching processes.
- Coalescence with mutations and demographic change. Relationship to
dynamical systems. Population dynamic coded in DNA
- Evolution of microsatellite loci: inference from data and connection
with mathematical models (two units).
- Dynamic mutations and trinucleotide-related diseases: Data and
models.
- Infinite Sites Model and mitochondria as molecular clocks.
- Evolution of mitochondria in somatic cells: origins of heteroplasmy,
mitochondrial diseases.

One additional unit is to be announced.



INVITED TALKS
=============

- Sufficient conditions for non-existence of periodic solutions in
some classes of delay differential equations (E. Beretta)
- From a stochastic system of interacting individuals to a non linear
diffusion continuous aggregation model. (V. Capasso)
- The Conditional Neyman-Pearson Lemma and model choice (W.P. Coleman)
- TBA (A. Goldbeter)
- Chemotaxis and aggregation in the cellular slime mould (T. Hoefer)
- Modelling age-structured populations (M. Iannelli)
- Free boundary problems for solid tumor evolution (L. Preziosi)
- Modelling Cell Populations Using  Branching processes: Theory And
Specific Applications (Z. Taib)



LABORATORIES
============

- Experimental techniques in oncology and molecular biology:
transfection (S. Alberti).
- Cancer and chemotherapy in animal models (S. Caltagirone, A. Di
Castelnuovo).
- Electrophysiology and microdialysis in the study of the CNS (M. Di
Mascio).
- Production of transgenic mice by pronuclear microinjection of
foreign DNA (C. Dossi).
- Potassium channels studied in Xenopus Laevis oocytes (M.Pessia).
- Regulation of cell-cycle, oncogenes and anti-oncogenes (A. Sala).
- Measurement of cellular DNA content by flow citometry (P. Ubezio,
N. Martelli).
- Electron microscopy in cell biology (R. Weigert).



> ------------------------------------------------------------------
APPLICATION
===========

Compile and return the following Application Form directly from the
school's webpage, or by e-mail to the address

             

The application form may also be sent in paper (mail or fax) to

Andrea De Gaetano
CNR - Centro Fisiopatologia Shock
Laboratorio di Biomatematica
UCSC - L.go A. Gemelli, 8
00168 Roma, Italia
Fax:  +39-06-3385446
Tel:  +39-06-3385446  +39-06-30155389  +39-06-30154082

/********************************************************************\
*         MATHEMATICS IN CELL PHYSIOLOGY AND PROLIFERATION           *
*          SUMMER  SCHOOL, TERMOLI, ITALY, 6-19 JUNE 1999            *
*                        APPLICATION FORM                            *
\********************************************************************/

GENERAL
=======

......................................................................
Surname, First Name, Title

......................................................................
Position

......................................................................
Institution

......................................................................
Address, Phone/Fax

......................................................................
Email (attention! will be used as the primary means of communication)

......................................................................
Main Area of Interest

[ ] Biologist/Medical     or      [ ] Mathematician/Engineer/Physicist

CONTRIBUTED PRESENTATION